13 November 2021
Bonymaen		v	Skewen
Bridgend Athletic		v	Kenfig Hill
Glynneath		v	Dunvant
Nantyffyllon		v	Brynamman
Tondu		v	Birchgrove
Waunarlwydd		v	Ammanford

27 November 2021
Ammanford		v	Tondu
Birchgrove		v	Nantyffyllon
Brynamman		v	Glynneath
Dunvant		v	Bridgend Athletic
Kenfig Hill		v	Bonymaen
Skewen		v	Waunarlwydd

4 December 2021
Bonymaen		v	Dunvant
Bridgend Athletic		v	Brynamman
Glynneath		v	Birchgrove
Nantyffyllon		v	Tondu
Skewen		v	Ammanford
Waunarlwydd		v	Kenfig Hill

11 December 2021
Ammanford		v	Nantyffyllon
Birchgrove		v	Bridgend Athletic
Brynamman		v	Bonymaen
Dunvant		v	Waunarlwydd
Kenfig Hill		v	Skewen
Tondu		v	Glynneath

18 December 2021
Bonymaen		v	Birchgrove
Bridgend Athletic		v	Tondu
Glynneath		v	Nantyffyllon
Kenfig Hill		v	Ammanford
Skewen		v	Dunvant
Waunarlwydd		v	Brynamman

8 January 2022
Ammanford		v	Glynneath
Birchgrove		v	Waunarlwydd
Brynamman		v	Skewen
Dunvant		v	Kenfig Hill
Nantyffyllon		v	Bridgend Athletic
Tondu		v	Bonymaen

15 January 2022
Bonymaen		v	Nantyffyllon
Bridgend Athletic		v	Glynneath
Dunvant		v	Ammanford
Kenfig Hill		v	Brynamman
Skewen		v	Birchgrove
Waunarlwydd		v	Tondu

29 January 2022
Ammanford		v	Bridgend Athletic
Birchgrove		v	Kenfig Hill
Brynamman		v	Dunvant
Glynneath		v	Bonymaen
Nantyffyllon		v	Waunarlwydd
Tondu		v	Skewen

19 February 2022
Bonymaen		v	Bridgend Athletic
Brynamman		v	Ammanford
Dunvant		v	Birchgrove
Kenfig Hill		v	Tondu
Skewen		v	Nantyffyllon
Waunarlwydd		v	Glynneath

5 March 2022
Birchgrove		v	Brynamman
Bonymaen		v	Ammanford
Bridgend Athletic		v	Waunarlwydd
Glynneath		v	Skewen
Nantyffyllon		v	Kenfig Hill
Tondu		v	Dunvant

12 March 2022
Ammanford		v	Birchgrove
Brynamman		v	Tondu
Dunvant		v	Nantyffyllon
Kenfig Hill		v	Glynneath
Skewen		v	Bridgend Athletic
Waunarlwydd		v	Bonymaen