23 April 2021
18:00	DHL Stormers	v	Cell C Sharks
20:15	Edinburgh	v	Zebre
20:15	Ulster	v	Connacht

24 April 2021
13:00	Benetton	v	Glasgow
15:00	Vodacom Bulls	v	Emirates Lions
17:15	Ospreys	v	Cardiff Blues
19:35	Leinster	v	Munster

25 April 2021
13:00	Dragons	v	Scarlets

30 April 2021
18:00	Cell C Sharks	v	Emirates Lions

1 May 2021
16:00	DHL Stormers	v	Vodacom Bulls

7 May 2021
18:00	Zebre	v	Benetton
20:15	Glasgow	v	Edinburgh
20:15	Munster	v	Ulster

8 May 2021
15:00	Emirates Lions	v	DHL Stormers
17:15	Vodacom Bulls	v	Cell C Sharks
19:35	Connacht	v	Leinster
19:35	Scarlets	v	Ospreys

9 May 2021
13:00	Cardiff Blues	v	Dragons

14 May 2021
18:00	Munster	v	Connacht
20:15	Leinster	v	Ulster

15 May 2021
15:00	Scarlets	v	Cardiff Blues
17:15	Benetton	v	Zebre
19:35	Edinburgh	v	Glasgow

16 May 2021
13:00	Dragons	v	Ospreys