6 May 2022
Furnace United	22	38	Llanelli Warriors

23 April 2022
Machynlleth	16	17	Aberystwyth

19 March 2022
Cefneithin	22	50	Llanelli Warriors

18 March 2022
Llangennech	46	36	Llanelli Warriors

26 February 2022
London Welsh	26	47	Llanelli Warriors

25 February 2022
Burry Port	43	7	Tumble
Narberth	15	7	Haverfordwest

19 February 2022
Pembroke	19	7	Pembroke Dock Quins

12 February 2022
Caerau Ely	43	22	Llanelli Warriors

11 February 2022
Haverfordwest	17	17	Pembroke

5 February 2022
Chester III	33	31	Narberth
Llanelli Warriors	26	44	Cardiff Internationals
Llangadog	26	7	Nantgaredig

23 January 2022
Swansea Gladiators	17	22	Llanelli Warriors

22 January 2022
Cefneithin	0	31	Waunarlwydd

21 January 2022
Llangennech	41	45	Llandovery

9 January 2022
Port Talbot Panthers	15	29	Llanelli Warriors

26 December 2021
Betws	17	31	Llanelli Warriors

18 December 2021
Loughor	49	19	Llanelli Warriors

11 December 2021
St Davids	7	45	Narberth

4 December 2021
Llangwm	10	22	Pembroke
MARIs	31	32	Llanelli Warriors

1 December 2021
Aberystwyth	49	7	Celtiaid

14 November 2021
Cardiff Chiefs	29	7	Llanelli Warriors

13 November 2021
Dunvant	20	19	Narberth

6 November 2021
Cefneithin	3	55	Narberth

4 November 2021
Tumble	14	17	Burry Port

30 October 2021
Cardiff Internationals	38	24	Llanelli Warriors
Milford Haven	19	13	Pembroke

23 October 2021
Aberystwyth	29	3	Llangadog
Carmarthen Ath Druids	34	19	Pembroke
Llangennech	0	32	Dunvant
Narberth	14	22	Treorchy

17 October 2021
Llanelli Warriors	10	51	Pembrokeshire Vikings

16 October 2021
Ammanford	12	26	Laugharne
Furnace United	17	12	Pontarddulais
Haverfordwest	21	12	Narberth

10 October 2021
Llanelli Warriors	10	36	Cardiff Chiefs

8 October 2021
Burry Port	35	21	Llangennech

3 October 2021
Llanelli Warriors	31	46	Welsh Ambulance Service

25 September 2021
Nantgaredig	0	7	Llangennech

21 September 2021
Aberystwyth	36	7	Aberaeron

18 September 2021
Pembroke	17	7	Narberth
Tenby United	27	24	Newcastle Emlyn

12 September 2021
Llanelli Warriors	71	29	Pantyffynnon

11 September 2021
Ammanford	45	21	Pontardawe
Lampeter Town	24	18	Pembroke

5 September 2021
Port Talbot Panthers	33	24	Llanelli Warriors

4 September 2021
Aberystwyth	26	14	Lampeter Town
Burry Port	22	0	Dunvant

29 August 2021
Betws	40	57	Llanelli Warriors

28 August 2021
Llandovery	7	19	Llangadog

21 August 2021
Aberystwyth	13	14	Machynlleth
Ammanford III	48	70	Llanelli Warriors
Burry Port	7	19	Carmarthen Ath Druids

20 August 2021
Ammanford	17	8	Llangadog
Tenby United	19	13	Narberth

14 August 2021
Ammanford	24	5	Vardre
Burry Port	5	19	Llandybie

6 August 2021
Ammanford	10	13	Felinfoel
Newcastle Emlyn	3	0	Llanybydder
Match abandoned - injury.

31 July 2021
Abercrave	17	14	Llanelli Warriors
Burry Port	10	5	Felinfoel
Lampeter Town	20	0	Newcastle Emlyn

29 July 2021
Furnace United	20	17	Trimsaran

24 July 2021
Kidwelly	19	12	Furnace United